Prognosis of Infantile Spasms and L-G Syndrome

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A model of symptomatic infantile spasms syndrome.

Infantile spasms are characterized by age-specific expression of epileptic spasms and hypsarrhythmia and often result in significant cognitive impairment. Other epilepsies or autism often ensue especially in symptomatic IS (SIS). Cortical or subcortical damage, including white matter, have been implicated in the pathogenesis of SIS. To generate a model of SIS, we recreated this pathology by inj...

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Infantile spasms in children with Down syndrome.

Down syndrome (DS) is the most common genetic cause of mental retardation. It is estimated that 5-13% of persons affected by DS have seizures. Infantile spasms are the most common type of seizures and usually are well controlled with steroids and antiepileptic drugs. We present 11 children at the age of 3 years and 4 months to 10 years and 7 months with DS and infantile spasms, treated at Child...

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West's Syndrome (infantile Spasms)--a Polymyographic Study.

A syndrome of brief repetitive massive spasms involving the muscles of the neck, trunk, and limbs, accompanied by either regression or loss of motor and mental skills, was described by Dr. W. J. West, a practitioner in Tonbridge, in his own son (1841). Dr. West had taken the child to London for a consultation with Sir Charles Clarke who had already seen four cases of what he called the 'salaam ...

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Infantile spasms syndrome in monozygotic twins.

The infantile spasms syndrome appeared on the same day in a pair of monozygotic twins at age 6 months. Clinical, electroencephalographic, and neuroradiological findings during the development of the disease are reported. One of the twins was treated with ACTH and in his case clinical and electroencephalographic improvement was more rapid than in the other who was treated with clonazepam. While ...

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Infantile spasms syndrome: a clinical overview

clinical overview The early epileptic encephalopathies are a group of conditions that all manifest with three major diagnostic criteria: medically refractory seizures, diffuse encephalopathy and a poor developmental outcome. These syndromes include early infantile epileptic encephalopathy (EEIE, also known as Otahara’s syndrome), severe myoclonic epilepsy of infancy (Dravet’s syndrome), infanti...

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ژورنال

عنوان ژورنال: Pediatric Neurology Briefs

سال: 1999

ISSN: 2166-6482,1043-3155

DOI: 10.15844/pedneurbriefs-13-3-4